What is Pramipexole? Using it in bodybuilding
Pramipexole is a
dopamine agonist and belongs to the same class of drugs as
Cabergoline. The main purpose of this drug is to treat Parkinson's
disease. Apo Pramipexole is most commonly found under the brand names
Sifrol, Mirapexin and Mirapex, and generics are also available.
Mirapex is the
most famous brand of the pharmaceutical company Boehringer Ingelheim
Pharmaceuticals. Along with the treatment of Parkinson's disease,
Pramipexole is used to treat restless legs syndrome. Also, the drug
has shown effectiveness in the treatment of bipolar disorder,
although it was not officially created for these purposes.
Functions and
properties of Pramipexole
Pramipexole is a
dopamine agonist that is directly related to the hormone prolactin.
When dopamine levels rise in the body, prolactin levels drop. The
drug has a direct effect on the dopamine D3 receptor. Although it
also acts on the D2 receptor, its affinity for the D3 receptor is
seven times stronger than that of any dopamine agonist in existence.
The action of
Pramipexole on the D3 receptor has a strong effect on the nervous
system, which is why it is used to treat Parkinson's disease, and in
some cases, Alzheimer's disease. Acting on the D3 receptor,
Pramipexole also affects sexual desire and activity in men.
Prolactin is
partially responsible for a man's refractory period, which refers to
the recovery time from sexual activity in order to increase
productivity again. By lowering prolactin and increasing dopamine,
Pramipexole can directly reduce the refractory period, which leads to
the ability to perform sexual function more often.
Action of
Pramipexole
The medical
benefits of Apo Pramipexole are manifested in the relief of symptoms
of Parkinson's disease and in improving the mood of patients.
However, the drug is used by athletes to improve performance,
primarily to combat a specific type of gynecomastia and improve
sexual function, which is often diminished with certain anabolic
steroids.
When prolactin
levels rise significantly, along with rising estrogen levels, it can
lead to gynecomastia (enlarged male breasts). Even by controlling
estrogen, gynecomastia can still occur in men who are sensitive to
Gynecomastia. The increase in prolactin levels during steroid use is
most commonly associated with the hormones Nandrolone (Deca
Durabolin) and Trenbolone.
Not all men will
have problems with an increase in prolactin while taking these
steroids, as this depends on dosage and genetic predisposition. If
control is needed, then Pramipexole is ideal for control. Elevated
levels of prolactin also have a negative effect on a man's sexual
activity, mainly in the inability to achieve and maintain an
erection.
The
most well-known steroid that leads to this condition is Nandrolone,
the hormone responsible for the phrase "Deca-dick". Those
who have problems with erection often refuse Nandrolone, which is
fully explained by its effect on potency.
However, in most
cases, low doses of Pramipexole can offset these problems. In fact,
the right combination of steroid hormones when combined with
Pramipexole can help you achieve peak sexual performance.
The last positive
effect of Apo Pramipexole is to increase the production of growth
hormone (GH). The increase in production, although not significant,
is sufficient reason for an increase in serum GH levels approximately
two hours after taking the drug.
Side effects
of Pramipexole
There are several
possible side effects of Apo Pramipexole, probably more than most
dopamine agonists. Side effects of Pramipexole depend on genetic
predisposition, some may not show them at all, while some may be very
annoying. Possible side effects of Pramipexole include:
Nausea (most
common side effect)
Vomiting
Loss of
appetite
Headaches
Swelling
(mainly in the legs, ankles and / or feet)
Insomnia and
dizziness (fainting is possible, but not often)
Hallucinations
(rare)
Muscle
cramps
General
weakness
The most common
cause of the above side effects is drug abuse. Pramipexole is a
powerful drug and should not be abused. The dosage of this dopamine
agonist should always be kept to a minimum.
Pramipexole
Review
Apo
Pramipexole is the strongest dopamine
agonist on the market and its ability to improve sexual function is
amazing. However, from a medical point of view, the drug is not often
prescribed for these purposes, but there is practically no data on
why this is so.
While potent, it
is also one of the strongest dopamine agonists in terms of
controlling side effects, especially when it comes to indigestion.
For many, Cabergoline may be the best option, which is easier to
control, but Pramipexole is the most acceptable option.